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Cyclobutane thymine dimers in a ras proto-oncogene hot spot activate the gene by point mutation.

ras proto-oncogenes with a cyclobutane-type thymine photodimer (cis-syn or trans-syn isomer) were constructed by replacement of a portion of the gene with a chemically synthesized fragment. When the genes were transfected by the calcium phosphate method into mouse NIH3T3 cells, they induced focus-fo...

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Detalhes bibliográficos
Main Authors: Kamiya, H, Murata, N, Murata, T, Iwai, S, Matsukage, A, Masutani, C, Hanaoka, F, Ohtsuka, E
Formato: Artigo
Idioma:Inglês
Publicado em: 1993
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC309532/
https://ncbi.nlm.nih.gov/pubmed/8389438
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