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Cyclobutane thymine dimers in a ras proto-oncogene hot spot activate the gene by point mutation.
ras proto-oncogenes with a cyclobutane-type thymine photodimer (cis-syn or trans-syn isomer) were constructed by replacement of a portion of the gene with a chemically synthesized fragment. When the genes were transfected by the calcium phosphate method into mouse NIH3T3 cells, they induced focus-fo...
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| Auteurs principaux: | , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
1993
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| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC309532/ https://ncbi.nlm.nih.gov/pubmed/8389438 |
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