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Cyclobutane thymine dimers in a ras proto-oncogene hot spot activate the gene by point mutation.
ras proto-oncogenes with a cyclobutane-type thymine photodimer (cis-syn or trans-syn isomer) were constructed by replacement of a portion of the gene with a chemically synthesized fragment. When the genes were transfected by the calcium phosphate method into mouse NIH3T3 cells, they induced focus-fo...
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| 出版年: | Nucleic Acids Res |
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| 主要な著者: | , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Oxford University Press
1993
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| オンライン･アクセス: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC309532/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8389438/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/21.10.2355 |
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