Photosensitized [2 + 2] cycloaddition of N-acetylated cytosine affords stereoselective formation of cyclobutane pyrimidine dimer

Photocycloaddition between two adjacent bases in DNA produces a cyclobutane pyrimidine dimer (CPD), which is one of the major UV-induced DNA lesions, with either the cis-syn or trans-syn structure. In this study, we investigated the photosensitized intramolecular cycloaddition of partially-protected...

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Bibliographic Details
Main Authors: Yamamoto, Junpei, Nishiguchi, Kosuke, Manabe, Koichiro, Masutani, Chikahide, Hanaoka, Fumio, Iwai, Shigenori
Format: Artigo
Language:Inglês
Published: Oxford University Press 2011
Subjects:
Synthetic Biology and Chemistry
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3035463/
https://ncbi.nlm.nih.gov/pubmed/20880992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq855
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