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Evaluating Prodrug Strategies for Esterase-Triggered Release of Alcohols

Prodrugs are effective tools in overcoming drawbacks typically associated with drug formulation and delivery. Those employing esterase-triggered functional groups are frequently utilized to mask polar carboxylic acids and phenols, increasing drug-like properties such as lipophilicity. Herein we deta...

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Hlavní autoři: Perez, Christian, Daniel, Kevin B., Cohen, Seth M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3918245/
https://ncbi.nlm.nih.gov/pubmed/23929690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201300255
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