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Sidedness of Carbamazepine Accessibility to Voltage-Gated Sodium Channels

Voltage-gated sodium channels are inhibited by many local anesthetics, antiarrhythmics, and antiepileptic drugs. The local anesthetic lidocaine appears to be able to access its binding site in the sodium channel only from the membrane phase or from the internal face of the channel. In contrast, the...

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Bibliografische gegevens
Hoofdauteurs: Jo, Sooyeon, Bean, Bruce P.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The American Society for Pharmacology and Experimental Therapeutics 2014
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3913360/
https://ncbi.nlm.nih.gov/pubmed/24319110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.113.090472
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