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Inhibition of Neuronal Voltage-Gated Sodium Channels by Brilliant Blue G
Brilliant blue G (BBG), best known as an antagonist of P2X7 receptors, was found to inhibit voltage-gated sodium currents in N1E-115 neuroblastoma cells. Sodium currents elicited from a holding potential of −60 mV were blocked with an IC(50) of 2 μM. Block was enhanced in a use-dependent manner at h...
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| Main Authors: | , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
The American Society for Pharmacology and Experimental Therapeutics
2011
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3141889/ https://ncbi.nlm.nih.gov/pubmed/21536754 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.110.070276 |
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