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Inhibition of Neuronal Voltage-Gated Sodium Channels by Brilliant Blue G

Brilliant blue G (BBG), best known as an antagonist of P2X7 receptors, was found to inhibit voltage-gated sodium currents in N1E-115 neuroblastoma cells. Sodium currents elicited from a holding potential of −60 mV were blocked with an IC(50) of 2 μM. Block was enhanced in a use-dependent manner at h...

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Detalhes bibliográficos
Main Authors: Jo, Sooyeon, Bean, Bruce P.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3141889/
https://ncbi.nlm.nih.gov/pubmed/21536754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.110.070276
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