Dexmedetomidine Inhibits Voltage-Gated Sodium Channels via α2-Adrenoceptors in Trigeminal Ganglion Neurons

Dexmedetomidine, an α2-adrenoceptor agonist, is widely used as a sedative and analgesic agent in a number of clinical applications. However, little is known about the mechanism by which it exerts its analgesic effects on the trigeminal system. Two types of voltage-gated sodium channels, Na(v)1.7 and...

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Gepubliceerd in:Mediators Inflamm
Hoofdauteurs: Im, Sang-Taek, Jo, Youn Yi, Han, Gayoung, Jo, Hyun Jung, Kim, Yong Ho, Park, Chul-Kyu
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Hindawi 2018
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6139198/
https://ncbi.nlm.nih.gov/pubmed/30245586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2018/1782719
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