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Voltage-gated sodium channels in the mammalian heart

Mammalian species express nine functional voltage-gated Na(+) channels. Three of them, the cardiac-specific isoform Na(v)1.5 and the neuronal isoforms Na(v)1.8 and Na(v)1.9, are relatively resistant to the neurotoxin tetrodotoxin (TTX; IC(50) ≥ 1 μM). The other six isoforms are highly sensitive to T...

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Detalhes bibliográficos
Publicado no:Glob Cardiol Sci Pract
Main Authors: Zimmer, Thomas, Haufe, Volker, Blechschmidt, Steve
Formato: Artigo
Idioma:Inglês
Publicado em: Bloomsbury Qatar Foundation Journals 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4355518/
https://ncbi.nlm.nih.gov/pubmed/25780798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5339/gcsp.2014.58
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