Systematic mapping of occluded genes by cell fusion reveals prevalence and stability of cis-mediated silencing in somatic cells

Both diffusible factors acting in trans and chromatin components acting in cis are implicated in gene regulation, but the extent to which either process causally determines a cell's transcriptional identity is unclear. We recently used cell fusion to define a class of silent genes termed “cis-s...

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Hauptverfasser: Looney, Timothy J., Zhang, Li, Chen, Chih-Hsin, Lee, Jae Hyun, Chari, Sheila, Mao, Frank Fuxiang, Pelizzola, Mattia, Zhang, Lu, Lister, Ryan, Baker, Samuel W., Fernandes, Croydon J., Gaetz, Jedidiah, Foshay, Kara M., Clift, Kayla L., Zhang, Zhenyu, Li, Wei-Qiang, Vallender, Eric J., Wagner, Ulrich, Qin, Jane Yuxia, Michelini, Katelyn J., Bugarija, Branimir, Park, Donghyun, Aryee, Emmanuel, Stricker, Thomas, Zhou, Jie, White, Kevin P., Ren, Bing, Schroth, Gary P., Ecker, Joseph R., Xiang, Andy Peng, Lahn, Bruce T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cold Spring Harbor Laboratory Press 2014
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3912417/
https://ncbi.nlm.nih.gov/pubmed/24310002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.143891.112
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