Dysregulation of the mTOR pathway in p53-deficient mice

Mammalian or mechanistic target of rapamycin (mTOR) is involved in growth, aging, and age-related diseases including cancer. There is an extensive cross talk between p53 and mTOR. In cell culture, p53 inhibits the mTOR pathway in a cell type-dependent manner. p53-deficient mice develop pro-inflammat...

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Bibliographische Detailangaben
Hauptverfasser: Leontieva, Olga V, Novototskaya, Liliya R, Paszkiewicz, Geraldine M, Komarova, Elena A, Gudkov, Andrei V, Blagosklonny, Mikhail V
Format: Artigo
Sprache:Inglês
Veröffentlicht: Landes Bioscience 2013
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3912042/
https://ncbi.nlm.nih.gov/pubmed/24184801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.26947
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