The choice between p53-induced senescence and quiescence is determined in part by the mTOR pathway

Transient induction of p53 can cause reversible quiescence and irreversible senescence. Using nutlin-3a (a small molecule that activates p53 without causing DNA damage), we have previously identified cell lines in which nutlin-3a caused quiescence. Importantly, nutlin-3a caused quiescence by activel...

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Bibliographic Details
Main Authors: Korotchkina, Lioubov G., Leontieva, Olga V., Bukreeva, Elena I., Demidenko, Zoya N., Gudkov, Andrei V., Blagosklonny, Mikhail V.
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2010
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2919254/
https://ncbi.nlm.nih.gov/pubmed/20606252
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