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Elimination of Proliferating Cells Unmasks the Shift from Senescence to Quiescence Caused by Rapamycin
BACKGROUND: Depending on cellular context, p53-inducing agents (such as nutlin-3a) cause different outcomes including reversible quiescence and irreversible senescence. Inhibition of mTOR shifts the balance from senescence to quiescence. In cell lines with incomplete responses to p53, this shift may...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Public Library of Science
2011
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3191182/ https://ncbi.nlm.nih.gov/pubmed/22022534 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0026126 |
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