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Elimination of Proliferating Cells Unmasks the Shift from Senescence to Quiescence Caused by Rapamycin

BACKGROUND: Depending on cellular context, p53-inducing agents (such as nutlin-3a) cause different outcomes including reversible quiescence and irreversible senescence. Inhibition of mTOR shifts the balance from senescence to quiescence. In cell lines with incomplete responses to p53, this shift may...

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Bibliografiske detaljer
Main Authors: Leontieva, Olga V., Demidenko, Zoya N., Gudkov, Andrei V., Blagosklonny, Mikhail V.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3191182/
https://ncbi.nlm.nih.gov/pubmed/22022534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0026126
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