Rapamycin extends lifespan and delays tumorigenesis in heterozygous p53+/− mice

The TOR (Target of Rapamycin) pathway accelerates cellular and organismal aging. Similar to rapamycin, p53 can inhibit the mTOR pathway in some mammalian cells. Mice lacking one copy of p53 (p53+/− mice) have an increased cancer incidence and a shorter lifespan. We hypothesize that rapamycin can del...

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Detalhes bibliográficos
Main Authors: Komarova, Elena A., Antoch, Marina P., Novototskaya, Liliya R., Chernova, Olga B., Paszkiewicz, Geraldine, Leontieva, Olga V., Blagosklonny, Mikhail V., Gudkov, Andrei V.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2012
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3517941/
https://ncbi.nlm.nih.gov/pubmed/23123616
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