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Weekly administration of rapamycin improves survival and biomarkers in obese male mice on high-fat diet

Recent discoveries have revealed the key role of mTOR (target of rapamycin) in aging. Furthermore, rapamycin extends lifespan in mice, especially in female mice. Here, we treated obese male mice on high-fat diet with rapamycin given intermittently: either weekly (once a week) or alternating bi-weekl...

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Publicat a:Aging Cell
Autors principals: Leontieva, Olga V, Paszkiewicz, Geraldine M, Blagosklonny, Mikhail V
Format: Artigo
Idioma:Inglês
Publicat: BlackWell Publishing Ltd 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4326934/
https://ncbi.nlm.nih.gov/pubmed/24655348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12211
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