While reinforcing cell cycle arrest, rapamycin and Torins suppress senescence in UVA-irradiated fibroblasts

Sunlight predisposes to skin cancer and melanomas. Ultraviolet A (UVA), a long wave component of sunlight, can reach dermal fibroblasts. Here we studied UVA-induced senescence in human fibroblasts in vitro. It is known that senescence occurs, when cell cycle is arrested, but mTOR is still active, th...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Leontieva, Olga V., Blagosklonny, Mikhail V.
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2017
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5752566/
https://ncbi.nlm.nih.gov/pubmed/29312653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.17827
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