Inosine-Mediated Modulation of RNA Sensing by Toll-Like Receptor 7 (TLR7) and TLR8

RNA-specific adenosine deaminase (ADAR)-mediated adenosine-to-inosine (A-to-I) editing is a critical arm of the antiviral response. However, mechanistic insights into how A-to-I RNA editing affects viral infection are lacking. We posited that inosine incorporation into RNA facilitates sensing of non...

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Détails bibliographiques
Auteurs principaux: Sarvestani, Soroush T., Tate, Michelle D., Moffat, Jessica M., Jacobi, Ashley M., Behlke, Mark A., Miller, Alistair R., Beckham, Simone A., McCoy, Claire E., Chen, Weisan, Mintern, Justine D., O'Keeffe, Meredith, John, Matthias, Williams, Bryan R. G., Gantier, Michael P.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2014
Sujets:
Virus-Cell Interactions
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3911656/
https://ncbi.nlm.nih.gov/pubmed/24227841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01571-13
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