Sequence-dependent off-target inhibition of TLR7/8 sensing by synthetic microRNA inhibitors

Anti-microRNA (miRNA) oligonucleotides (AMOs) with 2′-O-Methyl (2′OMe) residues are commonly used to study miRNA function and can achieve high potency, with low cytotoxicity. Not withstanding this, we demonstrate the sequence-dependent capacity of 2′OMe AMOs to inhibit Toll-like receptor (TLR) 7 and...

詳細記述

保存先:
書誌詳細
出版年:Nucleic Acids Res
主要な著者: Sarvestani, Soroush T., Stunden, H. James, Behlke, Mark A., Forster, Samuel C., McCoy, Claire E., Tate, Michelle D., Ferrand, Jonathan, Lennox, Kim A., Latz, Eicke, Williams, Bryan R.G., Gantier, Michael P.
フォーマット: Artigo
言語:Inglês
出版事項: Oxford University Press 2015
主題:
RNA
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4333393/
https://ncbi.nlm.nih.gov/pubmed/25539920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku1343
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