Sequence-dependent off-target inhibition of TLR7/8 sensing by synthetic microRNA inhibitors

Anti-microRNA (miRNA) oligonucleotides (AMOs) with 2′-O-Methyl (2′OMe) residues are commonly used to study miRNA function and can achieve high potency, with low cytotoxicity. Not withstanding this, we demonstrate the sequence-dependent capacity of 2′OMe AMOs to inhibit Toll-like receptor (TLR) 7 and...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Sarvestani, Soroush T., Stunden, H. James, Behlke, Mark A., Forster, Samuel C., McCoy, Claire E., Tate, Michelle D., Ferrand, Jonathan, Lennox, Kim A., Latz, Eicke, Williams, Bryan R.G., Gantier, Michael P.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
Assuntos:
RNA
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4333393/
https://ncbi.nlm.nih.gov/pubmed/25539920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku1343
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