Sequence-dependent off-target inhibition of TLR7/8 sensing by synthetic microRNA inhibitors

Anti-microRNA (miRNA) oligonucleotides (AMOs) with 2′-O-Methyl (2′OMe) residues are commonly used to study miRNA function and can achieve high potency, with low cytotoxicity. Not withstanding this, we demonstrate the sequence-dependent capacity of 2′OMe AMOs to inhibit Toll-like receptor (TLR) 7 and...

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Bibliografiske detaljer
Udgivet i:Nucleic Acids Res
Main Authors: Sarvestani, Soroush T., Stunden, H. James, Behlke, Mark A., Forster, Samuel C., McCoy, Claire E., Tate, Michelle D., Ferrand, Jonathan, Lennox, Kim A., Latz, Eicke, Williams, Bryan R.G., Gantier, Michael P.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2015
Fag:
RNA
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4333393/
https://ncbi.nlm.nih.gov/pubmed/25539920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku1343
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