Inosine-Mediated Modulation of RNA Sensing by Toll-Like Receptor 7 (TLR7) and TLR8

RNA-specific adenosine deaminase (ADAR)-mediated adenosine-to-inosine (A-to-I) editing is a critical arm of the antiviral response. However, mechanistic insights into how A-to-I RNA editing affects viral infection are lacking. We posited that inosine incorporation into RNA facilitates sensing of non...

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Detalhes bibliográficos
Main Authors: Sarvestani, Soroush T., Tate, Michelle D., Moffat, Jessica M., Jacobi, Ashley M., Behlke, Mark A., Miller, Alistair R., Beckham, Simone A., McCoy, Claire E., Chen, Weisan, Mintern, Justine D., O'Keeffe, Meredith, John, Matthias, Williams, Bryan R. G., Gantier, Michael P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3911656/
https://ncbi.nlm.nih.gov/pubmed/24227841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01571-13
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