Inosine-Mediated Modulation of RNA Sensing by Toll-Like Receptor 7 (TLR7) and TLR8

RNA-specific adenosine deaminase (ADAR)-mediated adenosine-to-inosine (A-to-I) editing is a critical arm of the antiviral response. However, mechanistic insights into how A-to-I RNA editing affects viral infection are lacking. We posited that inosine incorporation into RNA facilitates sensing of non...

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Detaylı Bibliyografya
Asıl Yazarlar: Sarvestani, Soroush T., Tate, Michelle D., Moffat, Jessica M., Jacobi, Ashley M., Behlke, Mark A., Miller, Alistair R., Beckham, Simone A., McCoy, Claire E., Chen, Weisan, Mintern, Justine D., O'Keeffe, Meredith, John, Matthias, Williams, Bryan R. G., Gantier, Michael P.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2014
Konular:
Virus-Cell Interactions
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3911656/
https://ncbi.nlm.nih.gov/pubmed/24227841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01571-13
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