The Connection Domain Mutation N348I in HIV-1 Reverse Transcriptase Enhances Resistance to Etravirine and Rilpivirine but Restricts the Emergence of the E138K Resistance Mutation by Diminishing Viral Replication Capacity

Clinical resistance to rilpivirine (RPV), a novel nonnucleoside reverse transcriptase (RT) inhibitor (NNRTI), is associated an E-to-K mutation at position 138 (E138K) in RT together with an M184I/V mutation that confers resistance against emtricitabine (FTC), a nucleoside RT inhibitor (NRTI) that is...

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Bibliographic Details
Main Authors: Xu, Hong-Tao, Colby-Germinario, Susan P., Oliveira, Maureen, Han, Yingshan, Quan, Yudong, Zanichelli, Veronica, Wainberg, Mark A.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2014
Subjects:
Vaccines and Antiviral Agents
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3911599/
https://ncbi.nlm.nih.gov/pubmed/24227862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02904-13
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