Potential of Host Defense Peptide Prodrugs as Neutrophil Elastase-Dependent Anti-Infective Agents for Cystic Fibrosis

Host defense peptides (HDPs) are short antimicrobial peptides of the innate immune system. Deficiencies in HDPs contribute to enhanced susceptibility to infections, e.g., in cystic fibrosis (CF). Exogenous HDPs can compensate for these deficiencies, but their development as antimicrobials is limited...

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Detaylı Bibliyografya
Asıl Yazarlar: Forde, Éanna, Humphreys, Hilary, Greene, Catherine M., Fitzgerald-Hughes, Deirdre, Devocelle, Marc
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2014
Konular:
Mechanisms of Action: Physiological Effects
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3910818/
https://ncbi.nlm.nih.gov/pubmed/24277028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01167-13
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