Potential of Host Defense Peptide Prodrugs as Neutrophil Elastase-Dependent Anti-Infective Agents for Cystic Fibrosis

Host defense peptides (HDPs) are short antimicrobial peptides of the innate immune system. Deficiencies in HDPs contribute to enhanced susceptibility to infections, e.g., in cystic fibrosis (CF). Exogenous HDPs can compensate for these deficiencies, but their development as antimicrobials is limited...

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Bibliographic Details
Main Authors: Forde, Éanna, Humphreys, Hilary, Greene, Catherine M., Fitzgerald-Hughes, Deirdre, Devocelle, Marc
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2014
Subjects:
Mechanisms of Action: Physiological Effects
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3910818/
https://ncbi.nlm.nih.gov/pubmed/24277028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01167-13
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