In Vitro Activities of Synthetic Host Defense Propeptides Processed by Neutrophil Elastase against Cystic Fibrosis Pathogens

The antimicrobial and hemolytic activities of a host defense peptide can be controlled by its modification as a propeptide of reduced net charge, which can then be processed by neutrophil elastase, a serine protease involved in chronic airway inflammation and infections associated with cystic fibros...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Desgranges, Stephane, Le Prieult, Florie, Daly, Alan, Lydon, Jennifer, Brennan, Marian, Rai, Dilip K., Subasinghage, Anusha P., Hewage, Chandralal M., Cryan, Sally-Ann, Greene, Catherine, McElvaney, Noel G., Smyth, Timothy P., Fitzgerald-Hughes, Deirdre, Humphreys, Hilary, Devocelle, Marc
التنسيق: Artigo
اللغة:Inglês
منشور في: American Society for Microbiology 2011
الموضوعات:
Mechanisms of Action: Physiological Effects
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC3088215/
https://ncbi.nlm.nih.gov/pubmed/21343449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01384-10
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