Human Cytomegalovirus UL97 Kinase Is Involved in the Mechanism of Action of Methylenecyclopropane Analogs with 6-Ether and -Thioether Substitutions

Methylenecyclopropane nucleoside (MCPN) analogs are being investigated for treatment of human cytomegalovirus (HCMV) infection because of favorable preclinical data and limited ganciclovir cross-resistance. Monohydroxymethyl MCPNs bearing ether and thioether functionalities at the purine 6 position...

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Main Authors: Komazin-Meredith, Gloria, Chou, Sunwen, Prichard, Mark N., Hartline, Caroll B., Cardinale, Steven C., Comeau, Katelyn, Williams, John D., Khan, Atiyya R., Peet, Norton P., Bowlin, Terry L.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2014
Fag:
Antiviral Agents
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3910744/
https://ncbi.nlm.nih.gov/pubmed/24145545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01726-13
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