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Cytomegalovirus UL97 Kinase Catalytic Domain Mutations That Confer Multidrug Resistance

Human cytomegalovirus UL97 kinase mutations that commonly confer ganciclovir resistance cluster in different parts of the gene than those conferring resistance to maribavir, an experimental UL97 kinase inhibitor. The drug resistance, growth, and autophosphorylation phenotypes of several unusual UL97...

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Autors principals: Chou, Sunwen, Ercolani, Ronald J., Marousek, Gail, Bowlin, Terry L.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3697320/
https://ncbi.nlm.nih.gov/pubmed/23650173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00511-13
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