TAOK3 Phosphorylates the Methylenecyclopropane Nucleoside MBX 2168 to its Monophosphate

Monohydroxymethyl methylenecyclopropane nucleosides (MCPNs) with ether or thioether substituents at the 6-position show promise as broad-spectrum herpes virus inhibitors. Their proposed mechanism of action involves sequential phosphorylation to a triphosphate, which can then inhibit viral DNA polyme...

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Foilsithe in:Antiviral Res
Main Authors: Komazin-Meredith, Gloria, Cardinale, Steven C., Comeau, Katelyn, Magalhaes, Kevin J., Hartline, Caroll B., Williams, John D., Opperman, Timothy J., Prichard, Mark N., Bowlin, Terry L.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2015
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4441832/
https://ncbi.nlm.nih.gov/pubmed/25857706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.antiviral.2015.04.001
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