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Efflux Inhibition with Verapamil Potentiates Bedaquiline in Mycobacterium tuberculosis
Drug efflux is an important resistance mechanism in Mycobacterium tuberculosis. We found that verapamil, an efflux inhibitor, profoundly decreases the MIC of bedaquiline and clofazimine to M. tuberculosis by 8- to 16-fold. This exquisite susceptibility was noted among drug-susceptible and drug-resis...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3910722/ https://ncbi.nlm.nih.gov/pubmed/24126586 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01462-13 |
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