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Verapamil Increases the Bactericidal Activity of Bedaquiline against Mycobacterium tuberculosis in a Mouse Model

Bedaquiline is a newly approved drug for the treatment of multidrug-resistant tuberculosis, but there are concerns about its safety in humans. We found that the coadministration of verapamil with subinhibitory doses of bedaquiline gave the same bactericidal effect in mice as did the full human bioeq...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Gupta, Shashank, Tyagi, Sandeep, Bishai, William R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4291418/
https://ncbi.nlm.nih.gov/pubmed/25331694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.04019-14
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