Enhanced cytotoxic effect of radiation and temozolomide in malignant glioma cells: targeting PI3K-AKT-mTOR signaling, HSP90 and histone deacetylases

BACKGROUND: Despite aggressive treatment with radiation therapy and concurrent adjuvant temozolomide (TMZ), glioblastoma multiform (GBM) still has a dismal prognosis. We aimed to identify strategies to improve the therapeutic outcome of combined radiotherapy and TMZ in GBM by targeting pro-survival...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Choi, Eun Jung, Cho, Bong Jun, Lee, David J, Hwang, Yeo Hyeon, Chun, Sun Ha, Kim, Hans H, Kim, In Ah
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3910677/
https://ncbi.nlm.nih.gov/pubmed/24418474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-14-17
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados