A Systems Pharmacology Perspective on the Clinical Development of Fatty Acid Amide Hydrolase Inhibitors for Pain

The level of the endocannabinoid anandamide is controlled by fatty acid amide hydrolase (FAAH). In 2011, PF-04457845, an irreversible inhibitor of FAAH, was progressed to phase II clinical trials for osteoarthritic pain. This article discusses a prospective, integrated systems pharmacology model eva...

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Библиографические подробности
Главные авторы: Benson, N, Metelkin, E, Demin, O, Li, G L, Nichols, D, van der Graaf, P H
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2014
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Original Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3910012/
https://ncbi.nlm.nih.gov/pubmed/24429592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/psp.2013.72
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