A Systems Pharmacology Perspective on the Clinical Development of Fatty Acid Amide Hydrolase Inhibitors for Pain

The level of the endocannabinoid anandamide is controlled by fatty acid amide hydrolase (FAAH). In 2011, PF-04457845, an irreversible inhibitor of FAAH, was progressed to phase II clinical trials for osteoarthritic pain. This article discusses a prospective, integrated systems pharmacology model eva...

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Detalhes bibliográficos
Main Authors: Benson, N, Metelkin, E, Demin, O, Li, G L, Nichols, D, van der Graaf, P H
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3910012/
https://ncbi.nlm.nih.gov/pubmed/24429592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/psp.2013.72
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