Potentiated Hsp104 variants antagonize diverse proteotoxic misfolding events

There are no therapies that reverse the proteotoxic misfolding events that underpin fatal neurodegenerative diseases including amyotrophic lateral sclerosis (ALS) and Parkinson disease (PD). Hsp104, a conserved hexameric AAA+ protein from yeast, solubilizes disordered aggregates and amyloid, but has...

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Main Authors: Jackrel, Meredith E., DeSantis, Morgan E., Martinez, Bryan A., Castellano, Laura M., Stewart, Rachel M., Caldwell, Kim A., Caldwell, Guy A., Shorter, James
Format: Artigo
Jezik:Inglês
Izdano: 2014
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3909490/
https://ncbi.nlm.nih.gov/pubmed/24439375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2013.11.047
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