Potentiated Hsp104 variants antagonize diverse proteotoxic misfolding events

There are no therapies that reverse the proteotoxic misfolding events that underpin fatal neurodegenerative diseases including amyotrophic lateral sclerosis (ALS) and Parkinson disease (PD). Hsp104, a conserved hexameric AAA+ protein from yeast, solubilizes disordered aggregates and amyloid, but has...

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Bibliographic Details
Main Authors: Jackrel, Meredith E., DeSantis, Morgan E., Martinez, Bryan A., Castellano, Laura M., Stewart, Rachel M., Caldwell, Kim A., Caldwell, Guy A., Shorter, James
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3909490/
https://ncbi.nlm.nih.gov/pubmed/24439375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2013.11.047
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