Potentiated Hsp104 variants antagonize diverse proteotoxic misfolding events

There are no therapies that reverse the proteotoxic misfolding events that underpin fatal neurodegenerative diseases including amyotrophic lateral sclerosis (ALS) and Parkinson disease (PD). Hsp104, a conserved hexameric AAA+ protein from yeast, solubilizes disordered aggregates and amyloid, but has...

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Detaylı Bibliyografya
Asıl Yazarlar: Jackrel, Meredith E., DeSantis, Morgan E., Martinez, Bryan A., Castellano, Laura M., Stewart, Rachel M., Caldwell, Kim A., Caldwell, Guy A., Shorter, James
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2014
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3909490/
https://ncbi.nlm.nih.gov/pubmed/24439375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2013.11.047
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