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Potentiated Hsp104 variants antagonize diverse proteotoxic misfolding events
There are no therapies that reverse the proteotoxic misfolding events that underpin fatal neurodegenerative diseases including amyotrophic lateral sclerosis (ALS) and Parkinson disease (PD). Hsp104, a conserved hexameric AAA+ protein from yeast, solubilizes disordered aggregates and amyloid, but has...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , , , , , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2014
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3909490/ https://ncbi.nlm.nih.gov/pubmed/24439375 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2013.11.047 |
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