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Insights into the Motif Preference of APOBEC3 Enzymes

We used a multivariate data analysis approach to identify motifs associated with HIV hypermutation by different APOBEC3 enzymes. The analysis showed that APOBEC3G targets G mainly within GG, TG, TGG, GGG, TGGG and also GGGT. The G nucleotides flanked by a C at the 3′ end (in +1 and +2 positions) wer...

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書誌詳細
主要な著者: Ebrahimi, Diako, Alinejad-Rokny, Hamid, Davenport, Miles P.
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2014
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3909203/
https://ncbi.nlm.nih.gov/pubmed/24498164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0087679
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