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Insights into the Motif Preference of APOBEC3 Enzymes
We used a multivariate data analysis approach to identify motifs associated with HIV hypermutation by different APOBEC3 enzymes. The analysis showed that APOBEC3G targets G mainly within GG, TG, TGG, GGG, TGGG and also GGGT. The G nucleotides flanked by a C at the 3′ end (in +1 and +2 positions) wer...
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| Autori principali: | , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Public Library of Science
2014
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3909203/ https://ncbi.nlm.nih.gov/pubmed/24498164 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0087679 |
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