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Amino Acids Activate Mammalian Target of Rapamycin (mTOR) Complex 1 without Changing Rag GTPase Guanyl Nucleotide Charging

Activation of mammalian target of rapamycin complex 1 (mTORC1) by amino acids is mediated in part by the Rag GTPases, which bind the raptor subunit of mTORC1 in an amino acid-stimulated manner and promote mTORC1 interaction with Rheb-GTP, the immediate activator. Here we examine whether the ability...

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Autors principals: Oshiro, Noriko, Rapley, Joseph, Avruch, Joseph
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3908400/
https://ncbi.nlm.nih.gov/pubmed/24337580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.528505
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