Direct inhibition of hexokinase activity by metformin at least partially impairs glucose metabolism and tumor growth in experimental breast cancer

Emerging evidence suggests that metformin, a widely used anti-diabetic drug, may be useful in the prevention and treatment of different cancers. In the present study, we demonstrate that metformin directly inhibits the enzymatic function of hexokinase (HK) I and II in a cell line of triple-negative...

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Hauptverfasser: Marini, Cecilia, Salani, Barbara, Massollo, Michela, Amaro, Adriana, Esposito, Alessia Isabella, Orengo, Anna Maria, Capitanio, Selene, Emionite, Laura, Riondato, Mattia, Bottoni, Gianluca, Massara, Cinzia, Boccardo, Simona, Fabbi, Marina, Campi, Cristina, Ravera, Silvia, Angelini, Giovanna, Morbelli, Silvia, Cilli, Michele, Cordera, Renzo, Truini, Mauro, Maggi, Davide, Pfeffer, Ulrich, Sambuceti, Gianmario
Format: Artigo
Sprache:Inglês
Veröffentlicht: Landes Bioscience 2013
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3906335/
https://ncbi.nlm.nih.gov/pubmed/24240433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.26461
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