Metformin Impairs Glucose Consumption and Survival in Calu-1 Cells by Direct Inhibition of Hexokinase-II

The anti-hyperglycaemic drug metformin has important anticancer properties as shown by the direct inhibition of cancer cells proliferation. Tumor cells avidly use glucose as a source for energy production and cell building blocks. Critical to this phenotype is the production of glucose-6-phosphate (...

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Detalhes bibliográficos
Main Authors: Salani, Barbara, Marini, Cecilia, Rio, Alberto Del, Ravera, Silvia, Massollo, Michela, Orengo, Anna Maria, Amaro, Adriana, Passalacqua, Mario, Maffioli, Sara, Pfeffer, Ulrich, Cordera, Renzo, Maggi, Davide, Sambuceti, Gianmario
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3691576/
https://ncbi.nlm.nih.gov/pubmed/23797762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep02070
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