IGF1 regulates PKM2 function through Akt phosphorylation

Pyruvate kinase M2 (PKM2) acts at the crossroad of growth and metabolism pathways in cells. PKM2 regulation by growth factors can redirect glycolytic intermediates into key biosynthetic pathway. Here we show that IGF1 can regulate glycolysis rate, stimulate PKM2 Ser/Thr phosphorylation and decrease...

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Vydáno v:Cell Cycle
Hlavní autoři: Salani, Barbara, Ravera, Silvia, Amaro, Adriana, Salis, Annalisa, Passalacqua, Mario, Millo, Enrico, Damonte, Gianluca, Marini, Cecilia, Pfeffer, Ulrich, Sambuceti, Gianmario, Cordera, Renzo, Maggi, Davide
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis 2015
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4612106/
https://ncbi.nlm.nih.gov/pubmed/25790097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2015.1026490
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