Direct inhibition of hexokinase activity by metformin at least partially impairs glucose metabolism and tumor growth in experimental breast cancer

Emerging evidence suggests that metformin, a widely used anti-diabetic drug, may be useful in the prevention and treatment of different cancers. In the present study, we demonstrate that metformin directly inhibits the enzymatic function of hexokinase (HK) I and II in a cell line of triple-negative...

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Main Authors: Marini, Cecilia, Salani, Barbara, Massollo, Michela, Amaro, Adriana, Esposito, Alessia Isabella, Orengo, Anna Maria, Capitanio, Selene, Emionite, Laura, Riondato, Mattia, Bottoni, Gianluca, Massara, Cinzia, Boccardo, Simona, Fabbi, Marina, Campi, Cristina, Ravera, Silvia, Angelini, Giovanna, Morbelli, Silvia, Cilli, Michele, Cordera, Renzo, Truini, Mauro, Maggi, Davide, Pfeffer, Ulrich, Sambuceti, Gianmario
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2013
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Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3906335/
https://ncbi.nlm.nih.gov/pubmed/24240433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.26461
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