Direct inhibition of hexokinase activity by metformin at least partially impairs glucose metabolism and tumor growth in experimental breast cancer

Emerging evidence suggests that metformin, a widely used anti-diabetic drug, may be useful in the prevention and treatment of different cancers. In the present study, we demonstrate that metformin directly inhibits the enzymatic function of hexokinase (HK) I and II in a cell line of triple-negative...

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Autori principali: Marini, Cecilia, Salani, Barbara, Massollo, Michela, Amaro, Adriana, Esposito, Alessia Isabella, Orengo, Anna Maria, Capitanio, Selene, Emionite, Laura, Riondato, Mattia, Bottoni, Gianluca, Massara, Cinzia, Boccardo, Simona, Fabbi, Marina, Campi, Cristina, Ravera, Silvia, Angelini, Giovanna, Morbelli, Silvia, Cilli, Michele, Cordera, Renzo, Truini, Mauro, Maggi, Davide, Pfeffer, Ulrich, Sambuceti, Gianmario
Natura: Artigo
Lingua:Inglês
Pubblicazione: Landes Bioscience 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3906335/
https://ncbi.nlm.nih.gov/pubmed/24240433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.26461
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