Divergent targets of glycolysis and oxidative phosphorylation result in additive effects of metformin and starvation in colon and breast cancer

Emerging evidence demonstrates that targeting energy metabolism is a promising strategy to fight cancer. Here we show that combining metformin and short-term starvation markedly impairs metabolism and growth of colon and breast cancer. The impairment in glycolytic flux caused by starvation is enhanc...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Marini, Cecilia, Bianchi, Giovanna, Buschiazzo, Ambra, Ravera, Silvia, Martella, Roberto, Bottoni, Gianluca, Petretto, Andrea, Emionite, Laura, Monteverde, Elena, Capitanio, Selene, Inglese, Elvira, Fabbi, Marina, Bongioanni, Francesca, Garaboldi, Lucia, Bruzzi, Paolo, Orengo, Anna Maria, Raffaghello, Lizzia, Sambuceti, Gianmario
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4726140/
https://ncbi.nlm.nih.gov/pubmed/26794854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep19569
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