Monoclonal antibody disulfide reduction during manufacturing: Untangling process effects from product effects

Manufacturing-induced disulfide reduction has recently been reported for monoclonal human immunoglobulin gamma (IgG) antibodies, a widely used modality in the biopharmaceutical industry. This effect has been tied to components of the intracellular thioredoxin reduction system that are released upon...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Hutterer, Katariina M., Hong, Robert W., Lull, Jonathon, Zhao, Xiaoyang, Wang, Tian, Pei, Rex, Le, M. Eleanor, Borisov, Oleg, Piper, Rob, Liu, Yaoqing Diana, Petty, Krista, Apostol, Izydor, Flynn, Gregory C.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Landes Bioscience 2013
Gaiak:
Report
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3906314/
https://ncbi.nlm.nih.gov/pubmed/23751615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.24725
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