Outcome-based determination of optimal pyrosequencing assay for MGMT methylation detection in glioblastoma patients

The methylation of O(6)-methylguanine DNA methyltransferase (MGMT) gene promoter is a key biological marker in clinical neuro-oncology. Nevertheless, there is no consensus concerning the best technique for its assessment. In a recent study comparing five methods to analyze MGMT status, we found that...

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Autori principali: Quillien, Véronique, Lavenu, Audrey, Sanson, Marc, Legrain, Michèle, Dubus, Pierre, Karayan-Tapon, Lucie, Mosser, Jean, Ichimura, Koichi, Figarella-Branger, Dominique
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer US 2014
Soggetti:
Laboratory Investigation
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3905192/
https://ncbi.nlm.nih.gov/pubmed/24420923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11060-013-1332-y
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