BRCA1 Tumor Suppression Depends on BRCT Phosphoprotein Binding, But Not Its E3 Ligase Activity

Germline mutations of the breast cancer 1 (BRCA1) gene are a major cause of familial breast and ovarian cancer. The BRCA1 protein displays E3 ubiquitin ligase activity, and this enzymatic function is thought to be required for tumor suppression. To test this hypothesis, we generated mice that expres...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Shakya, Reena, Reid, Latarsha J., Reczek, Colleen R., Cole, Francesca, Egli, Dieter, Lin, Chyuan-Sheng, deRooij, Dirk G., Hirsch, Steffen, Ravi, Kandasamy, Hicks, James B., Szabolcs, Matthias, Jasin, Maria, Baer, Richard, Ludwig, Thomas
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3904783/
https://ncbi.nlm.nih.gov/pubmed/22034435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1209909
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky