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E3 ligase activity of BRCA1 is not essential for mammalian cell viability or homology-directed repair of double-strand DNA breaks

Hereditary cases of breast and ovarian cancer are often attributed to germ-line mutations of the BRCA1 tumor suppressor gene. Although BRCA1 is involved in diverse cellular processes, its role in the maintenance of genomic integrity may be a key component of its tumor suppression activity. The prote...

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Bibliografische gegevens
Hoofdauteurs: Reid, Latarsha J., Shakya, Reena, Modi, Ami P., Lokshin, Maria, Cheng, Jiin-Tsuey, Jasin, Maria, Baer, Richard, Ludwig, Thomas
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2008
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2603436/
https://ncbi.nlm.nih.gov/pubmed/19088202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0811203106
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