The BRCT domains of the BRCA1 and BARD1 tumor suppressors differentially regulate homology-directed repair and stalled fork protection

The BRCA1 tumor suppressor preserves genome integrity through both homology-directed repair (HDR) and stalled fork protection (SFP). In vivo, BRCA1 exists as a heterodimer with the BARD1 tumor suppressor, and both proteins harbor a phosphate-binding BRCT domain. Here we compare mice with mutations t...

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Detalhes bibliográficos
Publicado no:Mol Cell
Main Authors: Billing, David, Horiguchi, Michiko, Wu-Baer, Foon, Taglialatela, Angelo, Leuzzi, Giuseppe, Alvarez Nanez, Silvia, Jiang, Wenxia, Zha, Shan, Szabolcs, Matthias, Lin, Chyuan-Sheng, Ciccia, Alberto, Baer, Richard
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6347115/
https://ncbi.nlm.nih.gov/pubmed/30244837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.08.016
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