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Orexin neurons suppress narcolepsy via 2 distinct efferent pathways

The loss of orexin neurons in humans is associated with the sleep disorder narcolepsy, which is characterized by excessive daytime sleepiness and cataplexy. Mice lacking orexin peptides, orexin neurons, or orexin receptors recapitulate human narcolepsy phenotypes, further highlighting a critical rol...

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Hlavní autoři: Hasegawa, Emi, Yanagisawa, Masashi, Sakurai, Takeshi, Mieda, Michihiro
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2014
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3904620/
https://ncbi.nlm.nih.gov/pubmed/24382351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI71017
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