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Orexin neurons suppress narcolepsy via 2 distinct efferent pathways

The loss of orexin neurons in humans is associated with the sleep disorder narcolepsy, which is characterized by excessive daytime sleepiness and cataplexy. Mice lacking orexin peptides, orexin neurons, or orexin receptors recapitulate human narcolepsy phenotypes, further highlighting a critical rol...

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Autors principals: Hasegawa, Emi, Yanagisawa, Masashi, Sakurai, Takeshi, Mieda, Michihiro
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3904620/
https://ncbi.nlm.nih.gov/pubmed/24382351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI71017
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